"All the World's a Stage We Pass Through" R. Ayana

Monday 18 October 2010

Russian Scientists Discover an Age-defying Drug

Russian Scientists Discover an Age-defying Drug
Fountain of Youth Pill On Sale Soon?

By Claire Bates

It may sound like science fiction but researchers believe they have discovered the 'Holy Grail' - an anti-ageing pill that will add decades to our lives.

Furthermore its creator Professor Vladimir Skulachev said it should be available to the public within two years

The Russian scientist from Moscow State University, said the drug works by halting the damaging effects that oxygen can have on the body's cells.

This would stave off dangerous age-related illnesses thereby adding years to our lives.

The dream of eternal life has been woven into numerous myths over thousands of years… But while many may dismiss the 69-year-old's claims as outlandish, his findings have been backed up by the international scientific community including Nobel prize winner Dr Gunter Blobel.

Dr Blobel from Rockefeller University said: 'It has been shown that oxidative damage is huge. But we do not have an anti-oxidant of the type that Professor Skulachev has developed.

'He is clearly the world's best bio-chemist and bio-energetic scientist.'

The cells in our bodies need oxygen to exchange energy but oxygen can also cause cells to die if it takes on active and poisonous forms.

Natural anti-oxidants have been found to help slow this fatal process but are not strong enough to have a lasting impact.

Professor Skulachev said: 'Ninety-nine per cent of the time oxygen turns into harmless water, but there's that one percent that turns into a super-oxide that later turns into very poisonous elements.

'So the task was to find an anti-oxidant that stops that process.'

Professor Skulachev said he has created innovative anti-oxidants nicknamed 'Skulachev's ions' after 40 years of hard work.

They neutralise the dangerous form of oxygen inside the cells and have been designed to travel to within a few nanometers of the position where they will have most impact in the cell.

Healthy old age: An anti-oxidant treatment will now be tested on volunteers

The professor said the most difficult part of the process has been trying to prevent any side effects. However, he said thousands of people have registered to take part in human trials and that the treatment will be available after around two more years of clinical testing.

In previous work the professor received acclaim for showing how special anti-oxidants could double the average lifespan of mice and keep them healthier for longer. He has also created synthesised eye drops that restored sight to a group of blind horses, dogs and rabbits.

Professor Skulachev even used himself as a human guinea-pig and removed a cataract from one of his eyes.

Biologist Maksim Skulachav, son of Professor Vladimir Skulachav said: 'Finally, we hope that we will manage to convince people that a single pill treats many threats of ageing. So, it must be doing something with the ageing itself.

'Then, if authorities will accept this logic, maybe we could somehow market it as anti-ageing drug.'

Analysis by Mark Frauenfelder

It appears that Skulachev has synthesized a mitochondrially targeted antioxidant. There's no detailed information in the article, but based on the papers Skulachev's group has published in the past, it looks like the compound in question is SkQ1, an antioxidant attached to a positively charged ion. Experiments have shown that SkQ1 prolongs the lifespan of a variety of species, including mice (link, link).
Clinical trials on humans are underway, and if everything goes smoothly, the drug will be out in a few years. After successful results from animal studies using eye drops, Skulachev tried it on his own cataract. After six months, his cataract was gone.
So what's the catch here? Well, looking at the lifespan data from mice, they're not talking about an increase in maximum lifespan but in median lifespan. The oldest mice receiving the drug did not live longer than the oldest mice in the control group, they just had a squared mortality curve. In other words, the mice that got SkQ1 made it to old age more often than the control mice.
 Images - http://www.paranormalmagazine.co.uk/wp-content/uploads/2010/05/man-sees-mary.jpg

For further enlightenment see –

The Her(m)etic Hermit - http://hermetic.blog.com

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