Sex Changes You: Sharing DNA Changes DNA

Sex Changes You

Sharing DNA Changes DNA

by EVOLVEFEST

DID YOU KNOW? Women (or men) absorb and carry living DNA and cells from every male they ever have had sexual intercourse with. In fact anyone who has assumed male spermatozoa into their bodily system has the living cells and genetic energetic imprint/signature of each individual whose sperm they have consumed or received IN ANY WAY.

Don't have sex with anyone who you wouldn't want to be - This advice, if followed, would transform the energy on Earth from war, hatred and strife to that of love, peace and concord.

This phenomenon is called "Male Microchimerism"
Microchimerism is the harboring of small numbers of cells that originated in a genetically different individual.

"BUT, when they autopsied the brains of women who had never even been pregnant they STILL found male DNA prevalent in the female brain.

They did their best to hide the evidence. They buried it in numerous sub studies but I sifted through it all and found the damning statement, the one they tried to avoid. The statement that every single article written about this extremely important study completely censored and left out.

What are they so afraid of??

"CONCLUSIONS: Male microchimerism was not infrequent in women without sons. Besides known pregnancies, other possible sources of male microchimerism include unrecognized spontaneous abortion, vanished male twin, an older brother transferred by the maternal circulation, or SEXUAL INTERCOURSE. Male microchimerism was significantly more frequent and levels were higher in women with induced abortion than in women with other pregnancy histories. Further studies are needed to determine specific origins of male microchimerism in women."

It’s so convenient how they flat out ignore the MOST OBVIOUS source of microchimerism male DNA hosting inside the female body. And the periodicals just deleted it altogether. The scumbags.

This has very important ramifications for women. Especially promiscuous women who practice unprotected sexual intercourse. Every male you absorb spermatazoa from becomes a living part of you FOR LIFE. The women autopsied in this study were elderly. Some had carried the living male DNA for well over 50 years!

This will certainly piss the feminists off. But it explains so much about women, life, and relationships.

Sperm is alive. It is living cells. When it is injected into you it swims and attaches and burrows into your flesh. If it’s in your mouth it swims and climbs into your nasal passages, inner ear, and behind your eyes. Then digs in. It enters your blood stream and collects in your brain and spine. Like something out of a sci fi movie…

The male DNA can also pass into and become part of a fetus from an entirely different male. So if your woman has a long track record, then your kids are likely carrying DNA from her past hookups.

Is this why the ancient Sumerian Gods specifically said to not have premarital sex? Is this why they forbid homosexuality?

We have only begun to understand the power and ramifications of this.
Links below:

Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history
http://www.ncbi.nlm.nih.gov/m/pubmed/16084184/

Women absorb and carry living DNA and cells from every male they have sexual intercouse with
http://www.godlikeproductions.com/forum1/message2299543/pg1

Male Microchimerism in the Human Female Brain
" In conclusion, male microchimerism is frequent and widely distributed in the human female brain."
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0045592#pone.0045592-Lambert1

From Evolvefest @ https://www.facebook.com/evolvefestival/photos/a.10151475909042011.1073741824.112052962010/10152837975942011/?type=1

Semen’s Chemical Cocktail Can Hijack a Mate’s Brain

 

image by SARIN KUNTHONG/ Shutterstock

 

By  Menno Schilthuizen

Let’s wallow in semen a little while longer, shall we? We have already seen that, even in humans, there is more to this substance than meets the eye. It contains proteins that, when mixed together, can forge a mating plug. It also contains sugars as sperm fuel, proteins that protect the sperm cells from the acidic vaginal environment, zinc that keeps the sperm’s DNA in good shape, and chemical compounds that prevent the sperm cells from becoming overenthusiastic prematurely.

But this list of ingredients is just the tip of the iceberg. Human ejaculates are home to hundreds of different proteins (which in certain women cause a kind of “sperm hay fever,” an allergic reaction to semen). And those are not trace amounts either; most of them occur in considerable concentrations, so they must be doing something important—we just don’t know what. Even in the ejaculate of the lowly banana fly Drosophila melanogaster, researchers have identified no fewer than 133 different kinds of proteins. One hundred and thirty-three! And this excludes the many proteins that are in the sperm cells themselves. These 133 are all produced by the banana fly version of the prostate, which releases them into the liquid portion of the semen.

 

Fastest Evolving Proteins We Know

 

Fortunately, banana flies being the lab biologist’s workhorse, we know quite a bit about what their seminal proteins do—or at least more than we know about their human counterparts.

To begin with, we know that they evolve as fast as the genitalia that deliver and receive them. Rama Singh of McMaster University in Hamilton, Canada, has been studying the protein cocktails in different species of banana flies and has discovered that the DNA codes for these genes, while remaining functional, are constantly and rapidly changing along the branches of the banana fly evolutionary tree. “The fastest evolving proteins we know,” he says. And a sure sign they are perpetually pushed around by sexual selection.

Banana fly researchers are quite confident that some of the ingredients of these biochemical cocktails are involved in a kind of neuropsychological manipulation. They hijack a female’s hormonal system by shutting down her sex drive, causing her to go completely off males for up to several days after having received a load of semen. Females that have recently been inseminated start kicking away their suitors or, when harassed, extend their egg-laying tube, which blocks access to the vagina. They even begin exuding a scent that renders them unattractive. All this is induced by semen components that end up in her bloodstream.

Usually, females prefer to have multiple fathers for a clutch of eggs—to generate healthy genetic diversity. But by usurping a female’s decision to add other males’ sperm to the mix that she is using to fertilize her eggs with, a male thus can prevent sperm competition. The whole process is akin to leaving a mental mating plug.

 

Killing the Mood

 

One of the substances that have such an “antiaphrodisiac” effect is sex peptide, a small protein molecule—small enough to pass straight through the wall of the vagina into the female’s bloodstream—that is produced in the glands that sit next to a male fly’s genitalia. It is present in the semen but also sticks to the tails of the sperm cells.

The sex peptide that is floating free in the semen does its work quickly: even before mating is fully over, it has already seeped through the vagina wall into the female’s blood, and within minutes begins to stick to receptors near her brain, where it makes the female’s interest in other males plummet. For up to seven hours, the initial shot of sex peptide causes females to give males the cold shoulder. Meanwhile, the sex peptide that sits on the sperm tails is beginning to break free, sustaining a steady IV drip of antiaphrodisiac that lasts for about a week—enough time to give the sperm a free passage, unchallenged by other males’ sperm.

 
Human sperm. Credit Carolina K. Smith MD/ Shutterstock

 

Chemical Cocktail

 

Sex peptide is only one of the multitude of chemical compounds in semen that a female banana fly receives each time she mates with a male. What do the rest do? Well, research in other insects can give us an inkling of what such substances might be capable of.

The semen of the American fire beetle Neopyrochroa flabellata, for example, is spiked with the poisonous compound cantharidin. Although in the human world this substance is known as the infamous aphrodisiac “Spanish fly,” the benefit gained by the male fire beetle is not his mate’s increased ardor, but rather the fact that the stuff ends up in the eggs fertilized by his sperm, which protects them against being eaten by ladybird beetles.

Another substance, the protein PSP1, is ejaculated by the male corn earworm moth into his mate and there immediately shuts down the production of pheromones, meaning that other males (which totally rely on scent) can no longer find her.

And then there’s Argas persicus. In this tick, believe it or not, the male produces a soda-bottle-like spermatophore from his genitalia, takes it into his jaws, bites off the cap, and then sticks it, neck first, into the female’s vagina. The appearance of carbon dioxide bubbles inside the spermatophore then forces out the sperm and other contents into the female. And at least one of these contents is a compound that cranks up the female’s egg production rate—which may mean more offspring to be sired by these sperm.

 

Human Semen

 

This list makes one wonder whether some of the many proteins in human semen could also have such manipulative effects. If they do, then this would be one way to explain the results of a study by Gordon Gallup and Rebecca Burch. In this study, they had almost three hundred female students fill out questionnaires relating to sex and mental health. The results showed that women who always use a condom—and so are protected against the effects of proteins in the semen—score almost 50 percent higher on a scale of depression-related symptoms than women who never use condoms, which might indicate (but doesn’t prove) that substances in semen interfere with the female nervous system.

And there is also evidence that pregnant women who have unprotected sex with their partner during pregnancy are less likely to suffer from so-called preeclampsia than women who use a condom. Since preeclampsia is a kind of inflammation of the woman’s body induced by her fetus—basically the mother becomes allergic to her own child—this might mean that substances in the semen take over part of the regulation of the woman’s immune system.

It seems that semen may be full of manipulative substances: the male using the female’s reproductive system to wage a chemical warfare against her reproductive autonomy or even, in an act of evolutionary paranoia, against potential future competitors.


 From Nature’s Nether Regions by Menno Schilthuizen, published on April 28, 2015 by Penguin Books, an imprint of Penguin Publishing Group, a division of Penguin Random House LLC. Copyright by Menno Schilthuizen, 2015.

From Discover @ http://blogs.discovermagazine.com/crux/2015/04/28/semen-chemical-brain/

For more information about epigenetics see http://nexusilluminati.blogspot.com/search/label/epigenetics

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Father’s Lifestyle Affects Future Offspring

Father’s Lifestyle Affects Future Offspring

No Sex Required: Body Cells Transfer Genetic Info Directly Into Sperm Cells, Amazing Study Finds

 

By Sayer Ji

 A revolutionary new study reveals that the core tenet of classical genetics is patently false, and by implication: what we do in this life -- our diet, our mindset, our chemical exposures -- can directly impact the DNA and health of future generations.


A paradigm shifting new study titled, "Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes," promises to overturn several core tenets of classical genetics, including collapsing the timescale necessary for the transfer of genetic information through the germline of a species (e.g. sperm) from hundreds of thousands of years to what amounts to 'real time' changes in biological systems.

In classical genetics, Mendelian laws specify that the inheritance of traits passed from one generation to the next can only occur through sexual reproduction as information is passed down through the chromosomes of a species' germline cells (egg and sperm), and never through somatic (bodily) cells.  Genetic change, according to this deeply entrenched view, can take hundreds, thousands and even millions of generations to manifest.

The new study, however, has uncovered a novel mechanism through which somatic-to-germline transmission of genetic information is made possible.  Mice grafted with human melanoma tumor cells genetically manipulated to express genes for a fluorescent tracer enzyme (EGFP-encoding plasmid) were found to release information-containing molecules containing the EGFP tracer into the animals' blood; since EGFP is a non-human and non-murine expressed tracer, there was little doubt that the observed phenomenon was real. These EGFP trackable molecules included exosomes (small nanoparticles produced by all eukaryotic cells (including plants and animals), which contain RNA and DNA molecules), which were verified to deliver RNAs to mature sperm cells (spermatozoa) and remain stored there.  The authors of the study pointed out that RNA of this kind has been found in mouse models to behave as a "transgenerational determinant of inheritable epigenetic variations and that spermatozoal RNA can carry and deliver information that cause phenotypic variations in the progeny."

The researchers concluded that their study's findings strongly suggest, "exosomes are the carriers of a flow of information from somatic cells to gametes," and that their "results indicate that somatic RNA is transferred to sperm cells, which can therefore act as the final recipients of somatic cell-derived information."

 

Breaking Through Weismann's Genetic Barrier

 

These findings overturn the so-called Weismann barrier, a principle proposed by the German evolutionary biologist August Weismann (1834 – 1914), that states hereditary information can only move from genes to body cells, and not the other way around, which has long been considered a nail in the coffin of the Lamarkian concept that an organism can pass on characteristics it has acquired during its lifetime to its offspring.

Over the past decade, however, the seeming impenetrability of the Weismann barrier has increasingly been called into question, due to a growing body of evidence that epigenetic patterns of gene expression (e.g. histone modifications, gene silencing via methylation) can be transferred across generations without requiring changes in the primary DNA sequences of our genomes; as well as the discovery that certain viruses contain the enzyme reverse transcriptase, which is capable of inscribing RNA-based information directly into our DNA, including germline cells, as is the case for endogenous retroviruses, which are believed responsible for about 5% of the nucleotide sequences in our genome. Nonetheless, as the authors of the new study point out, until their study, "no instance of transmission of DNA- or RNA-mediated information from somatic to germ cells has been reported as yet."

The researchers further expanded on the implications of their findings:

"Work from our and other laboratories indicates that spermatozoa act as vectors not only of their own genome, but also of foreign genetic information, based on their spontaneous ability to take up exogenous DNA and RNA molecules that are then delivered to oocytes at fertilization with the ensuing generation of phenotypically modified animals [35]–[37]. In cases in which this has been thoroughly investigated, the sperm-delivered sequences have been seen to remain extrachromosomal and to be sexually transmitted to the next generation in a non-Mendelian fashion [38]. The modes of genetic information delivery in this process are closely reminiscent of those operating in RNA-mediated paramutation inheritance, whereby RNA is the determinant of inheritable epigenetic variations [16], [17]. In conclusion, this work reveals that a flow of information can be transferred from the soma to the germline, escaping the principle of the Weismann barrier [39] which postulates that somatically acquired genetic variations cannot be transferred to the germline."

The implications of research on exosome-mediated information transfer are wide ranging. First, if your somatic cells, which are continually affected by your nutritional, environmental, lifestyle and even mind-body processes, can transfer genetic information through exosomes to the DNA within your germline cells, then your moment-to-moment decisions, behaviors, experiences, toxin and toxicant exposures, could theoretically affect the biological 'destinies' of your offspring, and their offspring, stretching on into the distant future. 

Exosome research also opens up promising possibilities in the realm of nutrigenomics and 'food as medicine.' A recent study found common plant foods, e.g. ginger, grapefruit, grapes, produce exosomes that, following digestion, enter human blood undegraded and subsequently down-regulate inflammatory pathways in the human body in a manner confirming some of their traditional folkloric medicinal uses.  If the somatic cells within our body are capable through extrachromosomal processes of modulating fundamental genetic processes within the germline cells, or, furthermore, if foods that we eat are also capable of acting as vectors of gene-regulatory information, truly the old reductionist, mechanistic, unilinear models of genetics must be abandoned in favor of a view that accounts for the vital importance of all our decisions, nutritional factors, environmental exposures, etc., in determining the course, not only of our bodily health, but the health of countless future generations as well.


From Green Med Info @ http://www.greenmedinfo.com/blog/no-sex-required-body-cells-transfer-genetic-info-directly-sperm-cells-amazing

Hereditary trauma: Inheritance of traumas and how they may be mediated

The consequences of traumatic experiences can be passed on from one generation to the next. [Click to enlarge image]

Extreme and traumatic events can change a person -- and often, years later, even affect their children. Researchers of the University of Zurich and ETH Zurich have now unmasked a piece in the puzzle of how the inheritance of traumas may be mediated.

The phenomenon has long been known in psychology: traumatic experiences can induce behavioural disorders that are passed down from one generation to the next. It is only recently that scientists have begun to understand the physiological processes underlying hereditary trauma. "There are diseases such as bipolar disorder, that run in families but can't be traced back to a particular gene," explains Isabelle Mansuy, professor at ETH Zurich and the University of Zurich. With her research group at the Brain Research Institute of the University of Zurich, she has been studying the molecular processes involved in non-genetic inheritance of behavioural symptoms induced by traumatic experiences in early life.

Mansuy and her team have succeeded in identifying a key component of these processes: short RNA molecules. These RNAs are synthetized from genetic information (DNA) by enzymes that read specific sections of the DNA (genes) and use them as template to produce corresponding RNAs. Other enzymes then trim these RNAs into mature forms. Cells naturally contain a large number of different short RNA molecules called microRNAs. They have regulatory functions, such as controlling how many copies of a particular protein are made.

Small RNAs with a huge impact

The researchers studied the number and kind of microRNAs expressed by adult mice exposed to traumatic conditions in early life and compared them with non-traumatized mice. They discovered that traumatic stress alters the amount of several microRNAs in the blood, brain and sperm -- while some microRNAs were produced in excess, others were lower than in the corresponding tissues or cells of control animals. These alterations resulted in misregulation of cellular processes normally controlled by these microRNAs.

After traumatic experiences, the mice behaved markedly differently: they partly lost their natural aversion to open spaces and bright light and had depressive-like behaviours. These behavioural symptoms were also transferred to the next generation via sperm, even though the offspring were not exposed to any traumatic stress themselves.

Even passed on to the third generation

The metabolism of the offspring of stressed mice was also impaired: their insulin and blood-sugar levels were lower than in the offspring of non-traumatized parents. "We were able to demonstrate for the first time that traumatic experiences affect metabolism in the long-term and that these changes are hereditary," says Mansuy. The effects on metabolism and behaviour even persisted in the third generation.

"With the imbalance in microRNAs in sperm, we have discovered a key factor through which trauma can be passed on," explains Mansuy. However, certain questions remain open, such as how the dysregulation in short RNAs comes about. "Most likely, it is part of a chain of events that begins with the body producing too much stress hormones."

Importantly, acquired traits other than those induced by trauma could also be inherited through similar mechanisms, the researcher suspects. "The environment leaves traces on the brain, on organs and also on gametes. Through gametes, these traces can be passed to the next generation."

Mansuy and her team are currently studying the role of short RNAs in trauma inheritance in humans. As they were also able to demonstrate the microRNAs imbalance in the blood of traumatized mice and their offspring, the scientists hope that their results may be useful to develop a blood test for diagnostics.

---

Story Source:

The above story is based on materials provided by ETH Zurich. Note: Materials may be edited for content and length.

---

Journal Reference:

1.     Gapp K, Jawaid A, Sarkies P, Bohacek J, Pelczar P, Prados J, Farinelli L, Miska E, Mansuy IM. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nature Neuroscience, April 13, 2014 DOI: 10.1038/nn.3695

2.      

From Science Daily @ http://www.sciencedaily.com/releases/2014/04/140413135953.htm#.U8DBHgn2LXM.email


For more information about epigenetics see http://nexusilluminati.blogspot.com/search/label/epigenetics
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